George Duo Wang

George Duo Wang

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Nominated for:

Pharmacy Award 2015





Job Title:

Associate Scientist/ Pharmacist

Educational Achievements:

Imperial College London
PhD, Chemical Engineering
2008 – 2012
Thesis: Advanced Physical Characterisation of Milled Pharmaceutical Powders

Supervisors: Dr. Daryl R. Williams, Dr. Jerry Y. Y. Heng

Funded by EPSRC in collaboration with GlaxoSmithKline (Mark. J. Bloxham)

Collaborating Academics: Dr. Joao Cabral, Prof. Alexander Bismarck & Prof. Frantisek Stephanek

Research Focus: understanding physical stability of crystalline pharmaceutical solids (APIs and excipients) post milling/micronisation and upon storage with an emphasis on relating surface properties to bulk behaviour, through development of a number of robust techniques for characterising amorphous, viscoelastic and partially amorphous pharmaceutical solids (physical volumetric expansion by optical dilatometry, viscoelasticity via stress relaxation, powder cohesion by unconfined yield stress and ultrafine amorphicity via MOUDI fractionation and DVS characterisation).

Viva - Prof. Robert Forbes (Professor of Biophysical Pharmaceutics), Prof. Paul Luckham (Professor of Colloid Science)
Activities and Societies: Badminton Society CSSA CACES

University of Nottingham
MPharm, Pharmacy
2003 – 2007
Final Year Project - with Dr. Max Paoli on Iron Sequestration Distribution system of Staphylococcus aureus

Tutor - Dr. Andrew Westwell and Dr. Helen Boardman
Activities and Societies: BPSA, Badminton Club/Society

Hills Road Sixth Form College, Cambridge
GCE A Levels, Biology, Chemistry, Mathematics and Physics, A, A, A and B
2001 – 2003
Activities and Societies: Badminton Team - Competed in Cambridge University Intramural League CEO of IOU Young Enterprise Company A Level Chemistry Extension and Chemistry International Olympiad Contestant

Cardiff High School
GCSE, English, Mathematics, Science Double Award, Geography, History, German, D & T, Welsh Foundation etc., A*, A, B and Cs
1998 – 2001
Activities and Societies: Badminton Club

Chaffey-Burke Elementary School, Burnaby, Vancouver
Elementary Education - Year 7, General Studies
1997 – 1998
Basketball Club
Activities and Societies: Tutor - Mr Montgomery Bell

Tredegarville C/W Primary School, Cardiff
Primary Education - SATs, Year 4-6, Level 7 for Mathematics
1994 – 1997

Portswood Primary School, Southampton
Primary Education, Year 4
1994 – 1994

WangJiaGuai Primary School, Chengdu, P.R. China
Primary Education, Year 3-4
1992 – 1994

Qing An Elementary School, Xi'an, P.R. China
Primary Education, Year 1-3
1989 – 1992
Activities and Societies: Interest in War Studies, Socialist Politics, Army

Professional Achievements:

Associate Scientist
April 2014 – Present (1 year 3 months)Ware, Hertfordshire
Contingency Worker in Respiratory Materials Science - GMS

Imperial Consultants Ltd/ICON Ltd
October 2010 – Present (4 years 9 months)London, United Kingdom
Part-time consultant at Imperial Consultants Ltd, consulting on solid-state materials analysis and characterisation projects with a number of industrial partners with emphasis on surface and particle properties.

Technical Expertise:

Solid State Materials Characterisation: proficient in a number of established solid state characterisation techniques for organic solids:

Surface area, water sorption and porosity (BET, dynamic vapour sorption),
Surface morphology (scanning electron microscopy, light microscopy, optical profilometry)
Particle size analysis (laser diffraction, dynamic light scattering, micro-orifice uniform deposit impactor)
Thermal characterisation (differential scanning calorimetry, thermogravimetric analysis)
Surface properties (quartz crystal microbalance, inverse gas chromatography)
Mechanical properties (cohesion, tablet hardness)
Structural properties (X-ray powder diffraction)

Solid State Materials Processing: proficient in crystallisation, spray-drying, milling/micronisation of active pharmaceutical ingredients and excipients at laboratory scale.

Locum Pharmacist
August 2010 – Present (4 years 11 months)London, United Kingdom
Part-time locum pharmacist at Sainsbury’s Pharmacy. Community pharmacist (GPhC registration no. 2067742) qualified for repeat dispensing, MUR & NMS, EPS, flu vaccination as well as a range of essential, advanced and enhanced services provided through Kensington & Chelsea PCT.

Locum Pharmacist
Tesco PLC
July 2008 – Present (7 years)Cambridge, United Kingdom
Part-time locum pharmacist at Tesco Pharmacy. Community pharmacist (GPhC registration no. 2067742) qualified for repeat dispensing, MUR & NMS, as well as a range of essential, advanced and enhanced services provided by Cambridgeshire PCT.

Post-Doctoral Research Associate
Imperial College London
December 2013 – April 2014 (5 months)London, United Kingdom
EPSRC Doctoral Prize Fellowship

Characterisation of Multi-component Inhaled Dry Powder Formulations

Supervisor: Dr. Jerry Y. Y. Heng

Particle engineering can play a crucial part in optimising inhaled dry powder formulation performance by increasing heterogeneous aggregation between the different APIs on the carrier whilst minimising unwanted deposition in the device or throat. This involves understanding the physical inter-, intra-particle and particle-surface interactions within the bulk powder and with the device. Based on previous work, sub-micron particles or ‘ultra-fines’ previously undetectable and/or unobtainable by conventional means were shown to have considerable contribution to the amorphous content and physical instability of micronised pharmaceutical powders. The proposed work is intended to expand on the findings and focus on determining the role of ultra-fines on formulation stability and performance, by correlating cohesiveness and surface energy heterogeneity.
(Open)1 project

Post-Doctoral Research Associate - Dept of Pharmaceutics, School of Pharmacy
University College London
May 2013 – November 2013 (7 months)London, United Kingdom
Working independently and within a large collaborative academic-industrial team to design optimum drug formulations for administration to patients in clinical trial human phases. Exploiting the chemical properties of the drug molecule (hydrophobicity, functionality, size) and novel pharmaceutics to design a dosage form which is most appropriate for the drug activity profile required/desired, whilst relating to disease pathophysiology and socio-demographic.

Supervisors: Prof. Ijeoma F. Uchegbu and Dr. Andreas G. Schatzlein
Pre-Registration Trainee Pharmacist
July 2007 – July 2008 (1 year 1 month)Canterbury, United Kingdom
Materials Science Department within Oral Product Centre of Emphasis - Development, Pharmaceutical Sciences (WWPS - PGRD Europe)

Pre-registration pharmacist at Pfizer Limited, Sandwich. Conducted research into physical stability of commercially marketed pharmaceutical hydrates (mono-, di- and tri-) and developed materials characterisation protocol and experimental matrix for future hydrate development.

Pre-Registration Tutor - Dr. Chris Smith/Mrs. Aileen Fisher/Ms. Laura Watson, Industrial Supervisor - Mrs. Pat Basford (Co-Supervisor - Dr. Stefan Taylor)

Made visits to a number of key business areas including RegCMC, Discovery, Biology, Clinical Trial Supply, Pilot Plant plus Marketing and Scientific Advisory in Pfizer UK HQ at Tadworth/Dorking

Pre-Registration Trainee Pharmacist
North Middlesex University Hospital NHS Trust
July 2007 – January 2008 (7 months)London, United Kingdom
Pre-registration pharmacist at North Middlesex University Hospital. Completed clinical requirements as part of RPSGB Pre-Registration and worked within multi-disciplinary team to provide clinical pharmacy services. Audit into Medicines Wastage in terms of TTAs and Patient's Own Medicines.
Cross-Sector Placements carried out Tesco Pharmacy Serpentine Green, Peterborough, St. Ann's Hospital Pharmacy (Mental Health Specialist) and North London Dental, Genito-Urinary and Geriatric Clinics.

Tutor - Mrs. Ryhana Haniff
Visiting Scholar - Public Health
University of Rochester Medical Center
August 2006 – September 2006 (2 months)Rochester, New York Area
Supervisors - Prof. Jonathan D. Klein and Mrs. Tracy Sesselberg

Working in partnership with Mrs. Rachel Carter

Nottingham Coordinator
Pharmacy Student
July 2006 – August 2006 (2 months)St. Ives, Cambridgeshire
Tutor - Duncan Graves

Pharmacy Student
Peterborough District Hospital NHS Foundation Trust
June 2006 – June 2006 (1 month)Peterborough, United Kingdom
Also spent time at Edith Cavell Hospital

Tutor - J Paul Deasy IP
Pharmacy Student
June 2005 – August 2005 (3 months)Cambridge, United Kingdom
Tutor - Simon Swallow

Additional Contributions:

Pharmaceutical nanocrystals(Link)
Current Opinion in Chemical Engineering
May 2012
Development of poorly soluble and/or permeable drug molecules using nanocrystal formulations has proven to be highly successful due to the greater surface/volume ratio, resulting in improvements in dissolution and bioavailability as well as enhanced permeability. These submicron ‘nanoparticles’ have similar benefits to conventional nanoparticles which are less than 100 nm but are scalable and can be applied in all existing manufacturing processes and dosage forms. This opinion focuses on recent developments in the preparation of nanocrystals and the role of surface properties on optimizing dissolution and targeted delivery. Some key technical challenges and environmental impact are also considered.

Effect of Processing Route on the Surface Properties of Amorphous Indomethacin Measured by Inverse Gas Chromatography(Link)
AAPS PharmSciTech
December 2012
The aim of this study was to investigate the effect of processing route (i.e., quench cooling and ball milling) on the surface energy heterogeneity and surface chemistry of indomethacin (IMC). Recently developed inverse gas chromatography (IGC) methodology at finite concentrations was employed to determine the surface energy distributions of crystalline, quench cooled and milled IMC samples. Surface properties of crystalline and processed IMC were measurably different as determined by the IGC and other conventional characterization techniques: differential scanning calorimetry and powder X-ray diffraction. Quench cooled IMC was in fully amorphous form. Milled IMC showed no amorphous character by calorimetric or X-ray diffraction studies. It was demonstrated that both processed IMC samples were energetically more active than the crystalline IMC. In particular, milled IMC exhibited a relatively higher dispersive surface energy and higher surface basicity (electron donor capability). This may be attributed to the creation of surface defect sites or exposure of higher energy crystal facets during the milling process. This study confirms that processing route has notable influence on the surface energy distribution and surface acid–base character. IGC was demonstrated as a powerful technique for investigating surface properties of real-world, heterogeneous pharmaceutical materials.

Dilatometry of powder compacts - Characterizing amorphous-crystalline transformations(Link)
Powder Technology
February 2013
A new dilatometry method has been developed for studying small cylindrical powder compacts based on non-contact white light interferometry which offers a z resolution of < 10 nm. In-situ compact dimensions were measured as a function of time with controlled relative humidity and temperature, allowing the study of recrystallization and other volumetric changes for amorphous lactose compacts. Complementary X-ray powder diffraction and dynamic vapor sorption data confirmed both water sorption and recrystallization kinetics. At 35% RH the compacts exhibited 0.6% height expansion consistent with vapor sorption in a glassy material. For 55% RH and 75% RH, small initial shrinkages (~ 2.5%) associated with the moisture induced plasticization of the lactose particles and their relaxation or collapse were observed, followed by a significant height expansion (~ 15%) of the compacts due to swelling of the rubbery lactose phase prior to crystallization. The kinetics at 55% and 75% RH indicated a smooth dimensional transition from water swollen to crystalline lactose compacts. A detailed surface area study by N2 BET adsorption of a range of compacts showed no statistically significant surface area changes above or below the Tg.



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